View allAdhesives & SealantsApplication NotesApplicationsArchiveARES G2 AccessoriesARES RheometerAutomated Density TesterAutomated Hardness TesterBatteriesBatteries & Battery MaterialsBatteriesBatteriesBiopharmaBiopharmaceuticalsBlog ApplicationsBlog Techniquescardiovascular instrumentsCase StudiesCeramicsCompositesCompositesDHR AccessoriesDifferential Scanning CalorimetersDifferential Scanning CalorimetryDIL 830 SeriesDilatometersDilatometry videosDilatometryDilatometryDiscovery Hybrid RheometersDraftsDynamic Mechanical Analysis (DMA)Dynamic Mechanical AnalyzersDynamic Mechanical Analyzers (DMA)Dynamic Mechanical Analyzers (Rheology)Dynamic Mechanical Analyzers (Thermal Analysis)ElastomersElectroForceElectroForceElectroForce NotesElectroForceElectroForceElectroForceElectronic Materials & ProductsElectronicsEnd of Life ProductsEngineered MaterialsFine & Specialty ChemicalsFlash Diffusivity SystemsFlash DiffusivityFlash Diffusivity VideosFood ProductsGeneralGlass ProductsGuarded heat flow meterHeating MicroscopesHigh Pressure AnalyzersHigh Throughput DSCHorizontal DilatometersIn-Person TrainingInorganics - OtherInorganics - MineralsInsulation & Building MaterialsIsothermal CalorimetryIsothermal Titration CalorimetryLaser FlashLoad frame systemsMaterial CharacterizationMechanical TestingMechanical TestingMedical Device TestingMedical DevicesMetals ProductsMicrocalorimetry videosMicrocalorimetryMicrocalorimetryMicrocalorimetryMicrocalorimetry NotesMicrocalorimetryMooney ViscometerMoving Die RheometerMulti-Specimen FatigueNews & InfoOils, Lubricants, & FluidsOptical DilatometersOptical FleximeterOrganic Chemicals & ProductsPaints, Inks, & CoatingsPercarbonatesPersonal Care & Household ProductsPetroleum ProductsPharmaceuticalsPharmaceuticalsPolymersPolymersprivateProduct videosProductsPromotionsQ SeriesQuenching DilatometersQuick start guidesRheology videosRheologyRheologyRheology AccessoryRheologyRheology NotesRheologyRotational ViscometerRubberRubber AccessoriesRubberRubber Process AnalyzersRubberRubber TestingRubber TestingRubber TestingRubothermSeminarsService VideosSimultaneous Thermal AnalyzerSoftwareSoftwareTA Quick Talk VideosTech TipsTestbench and Planar Biaxial systemsThermal Analysis videosThermal AnalysisThermal AnalysisThermal Analysis NotesThermal AnalysisThermal ApplicationsThermal Conductivity & DiffusivityThermal Conductivity MeterThermal ConductivityThermal Conductivity VideosThermogravimetric AnalysisThermomechanical AnalyzersThermophysical NotesThermophysical Properties NotesTrainingUncategorizedVapor Sorption AnalysisVertical DilatometersVideosDilatometryWebinarsMicrocalorimetryRheologyRubberThermal AnalysisXenon Flash

Microcalorimetry for the Biophysical Characterization of Macromolecules

Biological macromolecules are fundamental components of every cell and are therefore essential for all life. These vital molecules are categorized into four major classes: carbohydrates, lipids, proteins, and nucleic acids. Characterizing biological macromolecules is important for understanding their functions and relationships, which empowers the development of new therapies and treatments. Under this branch of macromolecule research, biotherapeutic drug therapy focuses on macromolecular interactions which can lead to disease and/or cell death.

Details

What is Isothermal Titration Calorimetry (ITC)?

Isothermal Titration Calorimetry (ITC) is an experimental method used to measure the amount of heat released or consumed during a bimolecular chemical reaction. Chemical reactions can be either exothermic or endothermic, depending on the relative energetic stabilities of the reactants. Isothermal titration calorimetry can be used to quantify the magnitude of the heat change during the reaction.

Details

How To Optimize Lyophilization with Thermal Analysis

Lyophilization, also called freeze-drying, is the process of removing water from a sample, often for preservation. Lyophilization involves the sublimation of a sample’s water content, usually through a rapid freezing process. Freezing materials quickly helps avoid the destruction of the cell walls in the sample from the formation of large ice crystals.

Details

Solving Problems for the Next Generation

The recent release of our 2022 Environmental, Social, and Governance (ESG) report demonstrates a continued commitment to leaving the world better than we found it. The pursuit of the goals outlined in this report remains a top priority for our company and this year’s edition reflects both our current focus areas and future ambitions.

Details

Lithium-ion Battery Quality and Performance Testing with Isothermal Microcalorimetry

Over the past decade, battery research, development, and quality control have adopted in-situ and in-operando isothermal microcalorimetry (IMC) as the leading method to evaluate heat flow during lithium-ion battery cycling. While cycling a cell to failure can take many months, emerging diagnostic tests are able to predict long-term behavior in a matter of weeks.

Details

How to Assess Binding in Drug Discovery

The most popular tool used to characterize binding in the late-discovery phase of drug development is isothermal titration calorimetry (ITC). ITC is a high-resolution method for complete characterization of the basic chemical details of a binding interaction. The calorimeters accomplish this by measuring the heat that is released or absorbed when molecules interact with each other.

Details