Chip filling

How to Accelerate Thermal Stability Testing for High-Concentration Drugs

Biopharmaceuticals, Microcalorimetry

The stability of high-concentration drugs can change under storage conditions, but until now, thermal testing in the lab using traditional calorimetry methods has been time-consuming and challenging. The new TA Instruments RS-DSC fills a critical antibody formulation development gap by allowing for high-throughput short-term thermal stability testing at formulation strength concentrations. In this blog, we explore why that’s essential.

Syringe and needle with glass medical ampoule vials for injection. Medicine is dry white drug penicillin powder or liquid with of aqueous solution in ampulla

Unlocking Stability: The Crucial Role of Thermal Analysis in Lyophilization Temperature Optimization

Biopharmaceuticals, Microcalorimetry

The method of drug delivery significantly influences the final stages of the manufacturing process. Currently, lyophilization—a widely adopted technique—enables drug developers to stabilize formulations and therapeutic molecules using a validated commercial approach. In this process, precise control of pressure and temperature within a lyophilizer facilitates the removal of liquids from formulations containing thermally sensitive or hydrolytically unstable active pharmaceutical ingredients or formulation components.

Lithium-ion Battery Quality and Performance Testing with Isothermal Microcalorimetry

Batteries & Battery Materials, Microcalorimetry

Over the past decade, battery research, development, and quality control have adopted in-situ and in-operando isothermal microcalorimetry (IMC) as the leading method to evaluate heat flow during lithium-ion battery cycling. While cycling a cell to failure can take many months, emerging diagnostic tests are able to predict long-term behavior in a matter of weeks.

Solving Problems for the Next Generation

Blog Techniques, Dilatometry, Mechanical Testing, Microcalorimetry, Rheology, Rubber Testing, Thermal Analysis, Thermal Conductivity & Diffusivity

The recent release of our 2022 Environmental, Social, and Governance (ESG) report demonstrates a continued commitment to leaving the world better than we found it. The pursuit of the goals outlined in this report remains a top priority for our company and this year’s edition reflects both our current focus areas and future ambitions.

What is Isothermal Titration Calorimetry (ITC)?

Biopharmaceuticals, Microcalorimetry, Thermal Analysis

Isothermal Titration Calorimetry (ITC) is an experimental method used to measure the amount of heat released or consumed during a bimolecular chemical reaction. Chemical reactions can be either exothermic or endothermic, depending on the relative energetic stabilities of the reactants. Isothermal titration calorimetry can be used to quantify the magnitude of the heat change during the reaction.