The Nano DSC utilizes capillary cells to achieve highest sensitivity and maximum sample flexibility.
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| Temperature Range | -10 °C to 130 °C |
| Scan Rates | 0.001 °C to 2 °C/min |
| Short-term Noise | 0.015 µWatts |
| Baseline Repeatability | 0.028 µWatts |
| Cell Configurations | Fixed Capillary / Cylindrical |
| Cell Materials | Platinum / Gold |
| Response Time | 5 sec |
| Active Cell Volume | 300 µL / 330 µL |
| Required Sample Volume | 500 µL / 450 µL |
| Pressure Control | Built-in 0 to 6 atmospheres |
| Heat Measurement Type | Power Compensation |
| Automation Specifications | |
| Sample Capacity | 2 standard 96-well plates, 490 µL/sample, 800 µL/reference |
| Sample Tray Temperature Range | Ambient to 4 °C |
| Wash / Rinse Solvent Ports | 5 on side of autosampler |
| 2 for autosampler syringe |
Innovative capillary design
Innovative Capillary Design
Innovative capillary design attenuates the onset of sample aggregation until after unfolding is complete.
Solid-state thermoelectric elements
Solid-State Thermoelectric Elements
Solid-state thermoelectric elements deliver accurate and precise temperature control of the sample.
Reliable autosampler
Reliable Autosampler
Reliable autosampler for increased productivity and true “walk-away” automation.
Protein required for DSC scan
Protein required for DSC scan
The Nano DSC delivers superior high sensitivity and reproducibility of data. Using the Nano DSC requires as little as 2 micrograms of protein, with quantitative results identical to experiments using 100 times more sample!
Protein Stability
Protein Stability
Nano DSC is ideal for accurate and precise measurements of protein stability. Unmatched repeatability of the heat flow baseline allows for the measurement of denaturation and partial molar heat capacity of proteins in very dilute solution.
Autosampler Productivity & Reproducibility
Autosampler Productivity & Reproducibility
The Nano DSC autosampler provides high sample throughput. With automated, unattended sample handling it is true “walk-away” automation. The high sensitivity and superior baseline stability allow scientists to work at low protein concentrations. Automated wash and rinse cycles eliminate the possibility of cell contamination. This data shows the high sensitivity and excellent reproducibility obtained by the auto Nano DSC on samples of different concentrations.
Nano DSC Brochure- Pressure Perturbation Calorimetry- Data Collection and Fitting
- Determining Thermal Stability of Antibodies with a Nano DSC
- Buffer Compatibility with Nano DSC
- Benchmarking the Performance of the Nano DSC Against Competitive Units
- Advantages of Nano DSC when Studying Proteins that Aggregate and Precipitate
Learn more about our superior cell design!- Nano DSC for Protein Stability
- True Walk-Away Automation
- Powerful New Nano DSC
Webinar: Thermodynamic Parameters in Drug Development – J. Ladbury- Webinar: Plasma Protein Calorimetry for Clinical Diagnostics – N. Garbett
- Description
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The Nano DSC differential scanning calorimeter is designed to characterize the molecular stability of dilute in-solution biomolecules. The Nano DSC obtains data using less sample than competitive designs. Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled variable pressure in the cell. Automated, unattended continuous operation with increased sample throughput is achieved with the optional Nano DSC Autosampler.The Nano DSC and Affinity ITC are used in gene therapy applications for characterizing serotype and drug loading in AAVs and LNPs, as well as target and off-target binding interactions.
- Specfications
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Temperature Range -10 °C to 130 °C Scan Rates 0.001 °C to 2 °C/min Short-term Noise 0.015 µWatts Baseline Repeatability 0.028 µWatts Cell Configurations Fixed Capillary / Cylindrical Cell Materials Platinum / Gold Response Time 5 sec Active Cell Volume 300 µL / 330 µL Required Sample Volume 500 µL / 450 µL Pressure Control Built-in 0 to 6 atmospheres Heat Measurement Type Power Compensation Automation Specifications Sample Capacity 2 standard 96-well plates,
490 µL/sample, 800 µL/referenceSample Tray Temperature Range Ambient to 4 °C Wash / Rinse Solvent Ports 5 on side of autosampler 2 for autosampler syringe - Technology
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Innovative capillary design
Innovative Capillary DesignInnovative capillary design attenuates the onset of sample aggregation until after unfolding is complete.
Solid-state thermoelectric elements
Solid-State Thermoelectric ElementsSolid-state thermoelectric elements deliver accurate and precise temperature control of the sample.
Reliable autosampler
Reliable AutosamplerReliable autosampler for increased productivity and true “walk-away” automation.
- Experiments
-
Protein required for DSC scan
Protein required for DSC scan
The Nano DSC delivers superior high sensitivity and reproducibility of data. Using the Nano DSC requires as little as 2 micrograms of protein, with quantitative results identical to experiments using 100 times more sample!
Protein Stability
Protein Stability
Nano DSC is ideal for accurate and precise measurements of protein stability. Unmatched repeatability of the heat flow baseline allows for the measurement of denaturation and partial molar heat capacity of proteins in very dilute solution.
Autosampler Productivity & Reproducibility
Autosampler Productivity & Reproducibility
The Nano DSC autosampler provides high sample throughput. With automated, unattended sample handling it is true “walk-away” automation. The high sensitivity and superior baseline stability allow scientists to work at low protein concentrations. Automated wash and rinse cycles eliminate the possibility of cell contamination. This data shows the high sensitivity and excellent reproducibility obtained by the auto Nano DSC on samples of different concentrations.
- Resources
-
- Nano DSC Brochure
- Pressure Perturbation Calorimetry- Data Collection and Fitting
- Determining Thermal Stability of Antibodies with a Nano DSC
- Buffer Compatibility with Nano DSC
- Benchmarking the Performance of the Nano DSC Against Competitive Units
- Advantages of Nano DSC when Studying Proteins that Aggregate and Precipitate
- Learn more about our superior cell design!
- Nano DSC for Protein Stability
- True Walk-Away Automation
- Powerful New Nano DSC
- Webinar: Thermodynamic Parameters in Drug Development – J. Ladbury
- Webinar: Plasma Protein Calorimetry for Clinical Diagnostics – N. Garbett
Nano DSC Photo Gallery
