Must Know Analytical Techniques for Biopharma Developers

eBook Must Know Analytical Techniques for Biopharma Developers A Guide to Improving Biologics Development with Materials Characterization Advancing next generation therapeutics requires reliable characterization of biotherapeutic binding and biomolecular stability. Characterizing biological macromolecules is important for understanding their functions and relationships, which empowers the development of new therapies and treatments. In the case of biotherapeutic…

Determination of the Relative Oxidative Stability of Polyethylene Bottle Tops by Differential Scanning Calorimetry (DSC)

Oxidative degradation of polymers is an exothermic process (releases heat) and is detectable by differential scanning calorimetry (DSC). Furthermore, DSC evaluation of polyethylene at elevated temperatures in the presence of oxygen is an effective method for accelerating the onset of degradation so that longer term (shelf life) properties can be predicted and/or compared.

Advances in Native Binding Assays

Isothermal titration calorimetry is a technique where heat is measured under constant pressure. This heat can be translated into enthalpy based on the First Law of Thermodynamics. Although the focus of the technique has been rooted in measuring biophysical phenomena in labs that specialized in calorimetry, it has seen growth as a general technique to quantitatively describe systems from proteins to nanomaterials.