We performed a comparability study of a liquid protein reference formulation using a nano differential scanning calorimeter (Nano DSC) to reveal that this thermodynamic technology detects the smallest changes in biomolecular structure in response to subtle manipulations in the reference formulation.
DetailsIsothermal titration calorimetry is a technique where heat is measured under constant pressure. This heat can be translated into enthalpy based on the First Law of Thermodynamics. Although the focus of the technique has been rooted in measuring biophysical phenomena in labs that specialized in calorimetry, it has seen growth as a general technique to quantitatively describe systems from proteins to nanomaterials.
DetailsAn overview of isothermal microcalorimetry in battery research, development and quality control in order to illustrate the versatility and providing an idea of the possibilities of isothermal microcalorimetry.
DetailsThermogravimetric Analysis (TGA), which provides information about the thermal stability and decomposition rate of materials, is an excellent technique for rapidly comparing the behavior of materials tested with different flame retardants.
DetailsNano Differential Scanning Calorimetry (Nano DSC) and Isothermal Titration Calorimetry (ITC) are powerful label-free and immobilization free analytic tools for thermodynamic measurements of molecular binding, biomolecular thermostability, and enzyme kinetic reactions.
DetailsNano Differential Scanning Calorimetry (Nano DSC) and Isothermal Titration Calorimetry (ITC) are powerful label-free and immobilization free analytic tools for thermodynamic measurements of molecular binding, biomolecular thermostability, and enzyme kinetic reactions.
DetailsThermogravimetric Analysis (TGA), which provides information about the thermal stability and decomposition rate of materials, is an excellent technique for rapidly comparing the behavior of materials tested with different flame retardants.
DetailsThe interaction between the antigen binding site and an antigen is extremely specific, which has made antibodies very highly desirable reagents when developing a wide variety of antigen detection assays.
DetailsAdeno-associated viruses (AAVs) are a leading gene therapy platform but pose challenges regarding encapsidation efficiency and quality control. This work highlights the use of the Nano DSC to overcome some of the challenges associated with AAVs.
DetailsThere has been significant work done looking at using IMC to characterize the growth patterns of bacteria3-9 and even converting isothermal microcalorimetry data into biologically meaningful data such as growth rate, lag phase, or maximum growth.
DetailsThis application note will review the microcalorimetric techniques that are most commonly used within pharmaceutical science: including stability and compatibility tests, determination of small amounts of amorphic content and characterizing polymorphism.
DetailsITC has recently received increased attention from the field of material science, which necessitates the use of non-aqueous solvent systems. Herein, we elaborate on the development of a representative binding assay that measures the interactions of Ca2+ with a calcium ionophore in a methanol solvent system.
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