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Category Archives: Blog Applications

Close up of test tubes

Thermal Analysis in Pharmaceutical Research, Development, and Quality Control

Pharmaceuticals, Thermal AnalysisBy Juli VarvarezisApril 18, 2024

As a central pillar of modern society, the pharmaceutical industry bears the load of billions of lives around the world. In 2022, the global revenue of the pharmaceutical industry approximated $1.5 trillion, a figure reflected in two decades of significant growth.

Rheo-IS

Evaluating Battery Slurries with Simultaneous Rheological and Impedance Measurement

Batteries & Battery Materials, RheologyBy Juli VarvarezisMarch 18, 2024

Lithium-ion batteries (LIB) are manufactured through a multistep process combining various active and inactive materials. Material selection and processing conditions can greatly affect the final battery performance.

Cherry pie

Rheology, Easy as Pie

Food Products, RheologyBy Juli VarvarezisMarch 14, 2024

I love a good experiment in the kitchen, especially when it involves baking and desserts. In celebration of Pi Day, let’s take science and experiments into the kitchen with pie dough and fillings…and a rheometer.

Vaccine needle​ syringe​ hypodermic​ injection single dose

Advance Formulation Performance with Rheology Studies

Biopharmaceuticals, RheologyBy Juli VarvarezisMarch 11, 2024

The progression from formulation development to commercial formulation is dependent on the dose strength, intrinsic stability, and extent of protein self-association in the final drug.1 This is because the drug is reaching the final stage of development.

Candidate selection

Optimizing Formulations After Candidate Selection

BiopharmaceuticalsBy Juli VarvarezisFebruary 14, 2024

Candidate selection is the third phase of the drug development process. The main purpose of candidate selection is to continue screening and filtering down to the most promising antibodies, ideally having one or two progress forward. During this phase, researchers are looking to evaluate the developability of a pool of less than five antibodies.

Black and white football helmets

Applying Dynamic Mechanical Analysis (DMA) to Test the Durability of Protective Sports Equipment

Mechanical Testing, Polymers, Thermal AnalysisBy Juli VarvarezisJanuary 31, 2024

There is a renewed interest in the durability of protective sports equipment after Patrick Mahomes’ helmet recently cracked apart in -4 degrees Fahrenheit (-20 degrees Celsius) weather. Scientists from TA Instruments ran tests to find out if materials found in protective sports equipment can break due to cold weather.

Electronic circuit board

Thermal Analysis for Printed Circuit Boards (PCBs)

Electronic Materials & Products, Thermal AnalysisBy Juli VarvarezisJanuary 22, 2024

Printed circuit boards (PCBs) form the backbone of virtually all electronic applications. Enhancing their performance and reliability is paramount for custom PCB projects, where smaller footprints and improved maintainability lead to enhanced functionality.

Antibody binding to human cell receptors

How to Assess Binding in Drug Discovery

Biopharmaceuticals, MicrocalorimetryBy Juli VarvarezisJanuary 9, 2024

The most popular tool used to characterize binding in the late-discovery phase of drug development is isothermal titration calorimetry (ITC). ITC is a high-resolution method for complete characterization of the basic chemical details of a binding interaction. The calorimeters accomplish this by measuring the heat that is released or absorbed when molecules interact with each other.

Gravy header

Using Rheology to Determine the Perfect Viscosity of Gravy

Food Products, RheologyBy Juli VarvarezisDecember 18, 2023

On holiday tables across the world, an unexpected unsung hero can make or break the meal: gravy. The seemingly simple condiment adds a dash of flavor to the star roast, livens up potatoes, and can rescue even the driest turkey that may accidentally make its way to the table.

Garolite blog header

4 Polymer Insights from Dynamic Mechanical Analysis

Composites, Mechanical Testing, PolymersBy Juli VarvarezisDecember 12, 2023

From material selection and failure analysis to end-use application, Dynamic Mechanical Analysis (DMA) offers crucial polymer insights. Polymer scientists and design engineers pair DMA with fatigue testing to gain a complete view of their material’s properties and performance attributes.

BioPharma Infographic

BioPharma Drug Development Workflow and Techniques

Biopharmaceuticals, MicrocalorimetryBy Juli VarvarezisNovember 27, 2023

Drug development is a long and complex process that starts with discovery and, if successful, ends with government approval for marketing. Each step in the drug development process, outlined below, has specific goals with the aim of down-selecting appropriate hits and candidates to an approved drug substance.

History of Microcalorimetry

Biopharmaceuticals, MicrocalorimetryBy Juli VarvarezisNovember 3, 2023

Throughout the 18th century, many scientists questioned the nature of heat. Isaac Newton thought that heat was transferred by the vibrations of particles, while Robert Hooke believed heat was a property of the body that arose from the motion of its parts.

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