Thermodynamic Rules To Achieve High Binding Affinity & Selectivity High affinity and selectivity are two essential properties of drug molecules. Since the binding affinity is determined by the sum of enthalpic and entropic contributions, extremely high affinity necessitates optimization of both contributions to binding. An efficient approach requires accurate prediction of the contributions of specific…
DetailsMeasuring Thermodynamic Parameters in the Drug Development Process Is there a benefit to measuring thermodynamic parameters in the drug development process? In this TA Instruments Webinar, Dr. John E. Ladbury discusses Thermodynamic Parameterization of protein-ligand interaction, not only provides quantification of the affinity of an interaction, but also the underlying changes in enthalpy and entropy.…
DetailsPlasma Protein Calorimetry For Clinical Diagnostics In this TA Instruments sponsored webinar, Dr. Nichola Garbett discusses the emerging technique of using high sensitivity DSC analysis of blood plasma for plasma proteome research, and as a clinical diagnostic tool.
DetailsUses of Isothermal Microcalorimetry in Urology In this TA Instruments sponsored webinar, Dr. Olivier Braissant discusses the process of detecting and monitoring biological processes with isothermal calorimetry. This has been shown to be an accurate analytical technique and is proportional to the rate at which a given chemical or physical process takes place.
DetailsIn Search of Calorimetric Answers to Events In Self Assemblies In this TA Webinar, Professor Nand Kishore discusses how to best discover and interpret protein folding, ligand binding, aggregation and molecular partitioning in self assemblies. Isothermal titration (ITC) and differential scanning calorimetry (DSC) are powerful tools for thermodynamic characterization of protein folding intermediates, drug-protein…
DetailsIntroducing the new TAM IV & TAM IV-48 Microcalorimeters The new TAM IV is the world’s most sensitive, stable, and flexible microcalorimeter system. It is completely modular and combines the highest heat flow sensitivity with unmatched long-term temperature stability to measure processes that are undetectable by other techniques.
DetailsDile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability This webinar is focused on enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics. Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of…
DetailsIntroducing the New TAM Air Isothermal Calorimeter This webinar introduces the all-new TAM Air Isothermal Calorimeter. Delivering the performance, reliability, and ease-of-use that is the hallmark of TA Instruments products, the new TAM Air maintains its leadership position as the instrument of choice for cement and concrete hydration analysis using ASTM C1702 and C1679, as…
DetailsStability Testing of Energetic Materials by Isothermal Microcalorimetry Overview This webinar introduces the use of isothermal microcalorimetry for stability measurement of energetic materials. Energetic materials refer to materials, chemicals and substances which exhibit a risk for self-decomposition associated with self-heating ultimately resulting in run-way reactions. Such materials include propellants, percarbonates and peroxides, and these…
DetailsLong Term Stability Analysis of Monoclonal Antibodies Overview Characterization of biopharmaceuticals during all development phases is critical to the candidate selection process and the ongoing production of the active material. Some recent efforts to achieve patient self-administration has required high API concentrations (100-300 mg/mL). Development concerns for the high concentration formulations are denaturation, aggregation…
DetailsIn this webinar, Dr. Colette Quinn discusses the use of differential scanning calorimetry (DSC) in protein stability characterization differences resulting from preparation changes of identical systems. Protein stability, particularly antibodies, can be determined via DSC without restrictions on buffers, excipients, and detergents. DSC, a native assay, works equally well for modified proteins such as antibody…
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