Measuring Thermodynamic Parameters in the Drug Development Process
Is there a benefit to measuring thermodynamic parameters in the drug development process? In this TA Instruments Webinar, Dr. John E. Ladbury discusses Thermodynamic Parameterization of protein-ligand interaction, not only provides quantification of the affinity of an interaction, but also the underlying changes in enthalpy and entropy. Though thermodynamic properties of interactions are now routinely measured, the information they convey is not well understood and their interpretation is difficult in the context of the numerous atomic level changes which occur on going from the free to the bound state. Here we investigate what thermodynamic parameterization reports on in a limited set of example protein-ligand interactions and ask whether these measurements can actually be of use in understanding biology and/or making decisions in pharmaceutical development.