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Category Archives: Application Notes

Micromechanical Multicyclic Creep Tests of Human Cortical Bone

Application Notes, ElectroForce NotesBy Super AdminJanuary 31, 2023

This study had a threefold purpose: 1) study the creep response of bone to repetitive phsyiologically-relevant loading 2) to perform these types of tests on a small scale; and, 3) to illustrate and identify age-related effects on the mechanical properties of bone.

Nano DSC: What to Consider when Choosing a Baseline and Model

Application Notes, Microcalorimetry NotesBy Super AdminJanuary 30, 2023

Choosing to model DSC data can give additional insight into the unfolding process of a macromolecule or be helpful to deconvolute a multiple transition thermogram. This application note will discuss general guidelines of choosing the correct baseline and DSC model.

A Study of the Nitinol Solid-Solid Transition by DSC

Application Notes, Thermal Analysis NotesBy Super AdminJanuary 30, 2023

The nitinol shape-memory alloy solid-solid transition is studied using differential scanning calorimetry (DSC), which reveals the reversible and hysteretic nature of this transition. This can be used to provide information on the composition of the nitinol alloy. It also serves as a tool to detect the existence of, and changes in, the intermediate R-phase.

Workflow Solutions: Choosing the Right ITC Binding Experiment

Application Notes, Microcalorimetry NotesBy Super AdminJanuary 27, 2023

Isothermal titration calorimetry (ITC) is the best technique to obtain a complete understanding of the driving forces leading to a binding interaction. There have been significant advances to the technology and method development leading to a workflow solution for every lab.

A Novel Thermodynamic Assay for Predicting and Monitoring Biomolecular Structure Stability

Application Notes, Microcalorimetry NotesBy Super AdminJanuary 26, 2023

We performed a comparability study of a liquid protein reference formulation using a nano differential scanning calorimeter (Nano DSC) to reveal that this thermodynamic technology detects the smallest changes in biomolecular structure in response to subtle manipulations in the reference formulation.

Determining the Mechanical Properties of Non-Woven PLGA Scaffolds

Application Notes, ElectroForce NotesBy Super AdminJanuary 25, 2023

To Characterize the Variation in Material Properties of Non-Woven PLGA Fibers

Isothermal Microcalorimetry: Pharmaceutical Applications of Microcalorimetry

Application Notes, Microcalorimetry NotesBy Super AdminJanuary 24, 2023

This application note will review the microcalorimetric techniques that are most commonly used within pharmaceutical science: including stability and compatibility tests, determination of small amounts of amorphic content and characterizing polymorphism.

Thermal Analysis of Polyamide 66 Gears with Added Recycle

Application Notes, Thermal Analysis NotesBy Super AdminJanuary 23, 2023

In this note, the thermal properties of nylon gears with increasing mass fractions of recycled material are evaluated.

Powder Rheology of Lactose: Impacts of powder morphology on performance of pharmaceutical excipients

Application Notes, Rheology NotesBy Super AdminJanuary 20, 2023

In this note, the processing behavior of two lactose excipients is studied by measuring shear and flowability of milled and spray-dried lactose. Milled lactose was found to have higher cohesion, yield strength, confined and unconfined flow energies when compared to spray-dried lactose.

Apparent Melting: A New Approach to Detecting Drug-Excipient Incompatibility

Application Notes, Thermal Analysis NotesBy Super AdminJanuary 18, 2023

The purpose of this paper is to explain and illustrate a systematic thermal analysis approach (DSC, MDSC®, and TGA) for detecting drug-excipient incompatibility and then optionally exploring the rate of reaction (kinetics) and reaction mechanism (chemistry).

Characterization of Bio-Derived Polymer Under Controlled Humidity

Application Notes, Rheology Notes, Thermal Analysis NotesBy Super AdminJanuary 17, 2023

In this apps note, the properties of PLA are studied under various controlled humidity and temperature conditions.

Using Rheology and Thermal Analysis to Help Optimize Processing Conditions of Recycled PET

Application Notes, Rheology NotesBy Super AdminJanuary 17, 2023

his application note describes the importance of using thermal and rheological techniques to help fingerprinting the molecular architecture of the PET feedstocks.

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