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Biophysical Characterization of Antibodies in a Suspension: Solutions for Slurries

  Overview Differential Scanning Calorimetry (DSC) is typically used during biopharmaceutical development to characterize a biomolecule through its thermal stability and unfolding profile. Here we demonstrate the suitability of DSC for studies of opaque solutions and slurries. Because of its universal indicator, heat, the technique can be applied to samples with magnetic or polystyrene beads,…

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Biophysical Characterization of Antibody Drug Conjugates Using DSC

Biophysical Characterization of Antibody Drug Conjugates Using DSC   In this webinar, Dr. Colette Quinn discusses the use of differential scanning calorimetry (DSC) in protein stability characterization differences resulting from preparation changes of identical systems. Protein stability, particularly antibodies, can be determined via DSC without restrictions on buffers, excipients, and detergents. DSC, a native…

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Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability

Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability This webinar is focused on enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics. Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of…

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Elucidating Thermodynamic Details of Biologic and Small Molecule Drugs using Microcalorimetry

Overview Researchers are working tirelessly to understand the basic chemical details of viral pathogenesis, viral protein structures, and identifying therapeutics to disrupt and prevent disease. There are different modes of therapies evolving that include small-molecule antiviral drugs, mRNA, and protein-based vaccines. Microcalorimetry is one powerful tool for the development and characterization of the mechanism of…

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In Search of Calorimetric Answers to Events In Self Assemblies

In Search of Calorimetric Answers to Events In Self Assemblies In this TA Webinar, Professor Nand Kishore discusses how to best discover and interpret protein folding, ligand binding, aggregation and molecular partitioning in self assemblies. Isothermal titration (ITC) and differential scanning calorimetry (DSC) are powerful tools for thermodynamic characterization of protein folding intermediates, drug-protein…

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Introducing the New TAM Air Isothermal Calorimeter

Introducing the New TAM Air Isothermal Calorimeter This webinar introduces the all-new TAM Air Isothermal Calorimeter. Delivering the performance, reliability, and ease-of-use that is the hallmark of TA Instruments products, the new TAM Air maintains its leadership position as the instrument of choice for cement and concrete hydration analysis using ASTM C1702 and C1679, as…

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