Cool Data, Better Drying: DSC as the Backbone of Lyophilization Optimization

Cool Data, Better Drying: DSC as the Backbone of Lyophilization Optimization

Thermal Analysis, Videos, Webinars

Webinar Cool Data, Better Drying: DSC as the Backbone of Lyophilization Optimization Freeze drying (lyophilization) is critical to biopharmaceutical stability, and understanding key thermal transitions is essential for developing robust, efficient processes. In this webinar, discover how Differential Scanning Calorimetry (DSC) and Modulated DSC® (MDSC®) help identify critical thermal properties, including the glass transition temperature…

Part II: Advanced Rheometric Applications for Aging/Mutating Systems

Part II: Advanced Rheometric Applications for Aging/Mutating Systems

Batteries, Rheology, Videos, Webinars

Webinar Part II: Advanced Rheometric Applications for Aging/Mutating Systems In this second part of the webinar series on rheometric applications, we explore advanced applications of Optimally Windowed Chirps (or OWCh) to characterize complex material systems, including aging thixotropic systems such as clay dispersions. We describe how user control of the initial phase and the frequency…

Part I: Basics of the Optimally-Windowed Exponential Chirp

Part I: Basics of the Optimally-Windowed Exponential Chirp

Batteries, Rheology, Videos, Webinars

Webinar Part I: Basics of the Optimally-Windowed Exponential Chirp In this two‑part webinar, we illustrate how modern broadband rheometric techniques can be used to measure the material functions of what may broadly be referred to as mutating materials (or changing materials), with rheological properties that are both time‑ and frequency‑dependent. Numerous approaches have been proposed…

Shawn C. Owen, Ph.D.

Assessing Production and Stability for Current and Emerging Antibody Drug Conjugate Platforms

Thermal Analysis, Videos, Webinars

Webinar Assessing Production and Stability for Current and Emerging Antibody Drug Conjugate Platforms Summary Clinically approved ADCs, despite high antibody sequence similarity, vary in linkers, payloads, and formulations. In this webinar we explore analytical techniques for ADC characterization—such as Intact Mass Spectrometry (DAR), peptide mapping, infrared spectroscopy, absorbance, DLS, and DSC—to evaluate structure, aggregation, and…

RS-DSC Demo VIdeo

Introducing the TA Instruments RS-DSC: A Dilution-Free Method for Screening Thermal Stability of High Concentration Biotherapeutics

Uncategorized

RS-DSC Product Demonstration A Dilution-Free Method for Screening Thermal Stability of High Concentration Biotherapeutics Resources Application Note: Rapid Thermal Stability Screening of High Concentration Biologic Drugs Application Note: Rapid Thermal Stability Screening and Selection of Monoclonal Antibody Drug Products Product Page: TA Instruments RS-DSC Request a Quote

Biophysical Characterization of Antibodies in a Suspension: Solutions for Slurries

Microcalorimetry, Videos, Webinars

  Overview Differential Scanning Calorimetry (DSC) is typically used during biopharmaceutical development to characterize a biomolecule through its thermal stability and unfolding profile. Here we demonstrate the suitability of DSC for studies of opaque solutions and slurries. Because of its universal indicator, heat, the technique can be applied to samples with magnetic or polystyrene beads,…

Shawn C. Owen, Ph.D.

Advanced Characterization of Antibody-Drug Conjugates and Antibody-Fusion Proteins

Thermal Analysis, Webinars

Overview: Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs) and antibody-fusion proteins. For ADCs, the level of payload and site of conjugation are determined…

Biophysical Characterization of Antibody Drug Conjugates Using DSC

Microcalorimetry, Videos, Webinars

In this webinar, Dr. Colette Quinn discusses the use of differential scanning calorimetry (DSC) in protein stability characterization differences resulting from preparation changes of identical systems. Protein stability, particularly antibodies, can be determined via DSC without restrictions on buffers, excipients, and detergents. DSC, a native assay, works equally well for modified proteins such as antibody…

Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability

Microcalorimetry, Videos, Webinars

Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability This webinar is focused on enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics. Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of…