Thermal analysis is a branch of material science that studies how a material’s properties change with temperature. From safe medicines to durable airplanes, countless products are made possible through thermal analysis. Understanding a material’s behavior under different temperatures is crucial for the successful design, processing, end use, and recyclability of completed products.
Die Glasübergangstemperatur (Tg) ist eine grundlegende Materialeigenschaft zur Definition der Materialintegrität, der Herstellungsbedingungen und der Betriebsrichtlinien für Anwendungen wie Polymere, Elektronik und moderne Werkstoffe.
Antibody-drug conjugates (ADCs) are a cutting-edge class of biopharmaceuticals transforming oncology treatment with increased specificity and efficacy. Their impact is only growing, as 14 ADCs have received global market approval to date and hundreds more are in development.
ITC is the most sensitive method for characterizing binding interactions, revealing critical attributes like drug efficacy and stability. But without proper mixing, ITC data is unreliable and unusable. Great ITC experiments start with correct mixing.
Discover the RS-DSC from TA Instruments, the ultimate high throughput DSC for rapid thermal analysis. Learn more about its precision, speed, and capabilities.
Biologic therapies derived from living organisms have revolutionized the treatment of complex diseases, yet their high development costs are often passed onto patients. Biosimilar drugs offer a promising solution to reduce costs while maintaining therapeutic efficacy. Unlike generic drugs, biosimilars cannot be exact replicas of their reference biologics due to their complex structures, necessitating rigorous testing and regulatory approval.
The stability of high-concentration drugs can change under storage conditions, but until now, thermal testing in the lab using traditional calorimetry methods has been time-consuming and challenging. The new TA Instruments RS-DSC fills a critical antibody formulation development gap by allowing for high-throughput short-term thermal stability testing at formulation strength concentrations. In this blog, we explore why that’s essential.
Der Weg von der Entwicklung einer Formulierung hin zur kommerziellen Formulierung hängt von der Dosisstärke, der intrinsischen Stabilität und dem Ausmaß der Proteinselbstassoziation im fertigen Arzneimittel ab, wenn das Arzneimittel das Endstadium der Entwicklung erreicht.1
The method of drug delivery significantly influences the final stages of the manufacturing process. Currently, lyophilization—a widely adopted technique—enables drug developers to stabilize formulations and therapeutic molecules using a validated commercial approach. In this process, precise control of pressure and temperature within a lyophilizer facilitates the removal of liquids from formulations containing thermally sensitive or hydrolytically unstable active pharmaceutical ingredients or formulation components.
Die Arzneistoffentwicklung ist ein langer und komplexer Prozess, der mit der Wirkstoffforschung beginnt und im Erfolgsfall mit der behördlichen Genehmigung für das Inverkehrbringen endet. In jedem Schritt des Arzneistoffentwicklungsprozess, der im Folgenden beschrieben wird, gibt es konkrete Zielsetzungen, mit denen letztendlich der am besten geeignete Kandidat zur Herstellung eines zugelassenen Arzneimittelwirkstoffs ausgewählt wird.
The most popular tool used to characterize binding in the late-discovery phase of drug development is isothermal titration calorimetry (ITC). ITC is a high-resolution method for complete characterization of the basic chemical details of a binding interaction. The calorimeters accomplish this by measuring the heat that is released or absorbed when molecules interact with each other.
Drug development is a long and complex process that starts with discovery and, if successful, ends with government approval for marketing. Each step in the drug development process, outlined below, has specific goals with the aim of down-selecting appropriate hits and candidates to an approved drug substance.