利用流變學研究改進配方性能
從配方開發到商業配方的進展，皆取決於最終藥物的劑量強度、內在穩定性和蛋白質自結合程度。1 這是因為該藥物的研發已進入最後階段。
3 Essential Types of Mechanical Testing for Polymer Development
High-performance polymers are a critical material for manufacturers due to their combination of mechanical, thermal, and chemical properties, but especially their cost. Without adequate testing, manufacturers could run into a slew of issues, from immediate product failure to poor performance or failure after some time in usage.
Unlocking Stability: The Crucial Role of Thermal Analysis in Lyophilization Temperature Optimization
The method of drug delivery significantly influences the final stages of the manufacturing process. Currently, lyophilization—a widely adopted technique—enables drug developers to stabilize formulations and therapeutic molecules using a validated commercial approach. In this process, precise control of pressure and temperature within a lyophilizer facilitates the removal of liquids from formulations containing thermally sensitive or hydrolytically unstable active pharmaceutical ingredients or formulation components.
Characterization Considerations when Sourcing PCR
Against the backdrop of a plastic waste crisis, the global demand for plastic is set to quadruple by 2060. This has driven a shift toward sustainability and away from linear use models of plastic production. Post-consumer resin (PCR) has emerged as a key player in circular economy initiatives, though ensuring the quality and performance of PCR requires several characterization considerations.
Thermal Analysis in Pharmaceutical Research, Development, and Quality Control
As a central pillar of modern society, the pharmaceutical industry bears the load of billions of lives around the world. In 2022, the global revenue of the pharmaceutical industry approximated $1.5 trillion, a figure reflected in two decades of significant growth.
印刷電路板 (PCB) 的熱分析
Printed circuit boards (PCBs) form the backbone of virtually all electronic applications. Enhancing their performance and reliability is paramount for custom PCB projects, where smaller footprints and improved maintainability lead to enhanced functionality.
How to Assess Binding in Drug Discovery
The most popular tool used to characterize binding in the late-discovery phase of drug development is isothermal titration calorimetry (ITC). ITC is a high-resolution method for complete characterization of the basic chemical details of a binding interaction. The calorimeters accomplish this by measuring the heat that is released or absorbed when molecules interact with each other.
4 Polymer Insights from Dynamic Mechanical Analysis
From material selection and failure analysis to end-use application, Dynamic Mechanical Analysis (DMA) offers crucial polymer insights. Polymer scientists and design engineers pair DMA with fatigue testing to gain a complete view of their material’s properties and performance attributes.
生物製藥藥物開發工作流程和技術
Drug development is a long and complex process that starts with discovery and, if successful, ends with government approval for marketing. Each step in the drug development process, outlined below, has specific goals with the aim of down-selecting appropriate hits and candidates to an approved drug substance.
微量熱法的歷史
在整個 18 世紀，許多科學家都對熱的本質提出了質疑。艾薩克·牛頓 (Isaac Newton) 認為熱能是透過粒子的震動傳遞的，而勞勃·虎克 (Robert Hooke) 則認為熱能是人體各部位運動而產生的一種特性1。然而，在歷史上第一個眾所周知對熱量進行測量的貢獻者是蘇格蘭醫生和化學家約瑟夫·布拉克 (Joseph Black)1。1761 年，他透過精確的測量發現，對達熔點的冰或達沸點的水施加熱量並不會導致溫度變化1。這個觀察結果使他成為第一個區分溫度和熱量的科學家，標誌了熱力學的開端。
複合材料的材料分析
We expect a lot from our composites: rocket materials need to endure the heat of takeoff, wind turbines must withstand high wind gusts, and sneakers are expected to be durable and supportive on long runs. How do experts develop composites tailored to such specific uses and verify their properties?
如何利用流變學改良電池電極漿料
從輕薄的筆記型電腦到長途電動汽車，無數應用都需要提高鋰電池的能量密度和性能。由於電池電極直接影響電池的能量密度和性能，因此電池研究人員對電極及其組成特別感興趣，希望將技術推向更高境界。電池漿料加工處理也是製程中的關鍵步驟，是提升效率並降低成本的重大機會。