Advanced Characterization of Antibody-Drug Conjugates and Antibody-Fusion Proteins

  Overview: Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs) and antibody-fusion proteins. For ADCs, the level of payload and site of conjugation are…

Benefits of Microscopy for Interpretation of DSC Thermograms

Benefits of Microscopy for Interpretation of DSC Thermograms DSC thermograms can be complicated and difficult to interpret, sometimes requiring multiple experiments in order to better understand a thermal event. The NEW Microscope Accessory for the Discovery DSC helps to eliminate these issues by allowing the user to easily view the sample while the DSC experiment…

DSC Characterization of Crystalline Structure in Foods and Pharmaceuticals

DSC Characterization of Crystalline Structure in Foods and Pharmaceuticals Differential Scanning Calorimetry (DSC) is an analytical technique frequently used to detect and quantify crystalline content of pharmaceuticals, foods, polymers, and many other materials. Appearing as an endothermic peak during heating in a DSC experiment, the temperature and area of the peak can be used to…

Isothermal Microcalorimetry in Pharmaceutical Science

Isothermal Microcalorimetry in Pharmaceutical Science This webinar will review the microcalorimetric techniques that are most commonly used within pharmaceutical science, including stability and compatibility tests, determination of small amounts of amorphic content, and characterizing polymorphism. A microcalorimeter can quantify the amount and rate of heat release from chemical processes associated with stability and shelf…

Interfacial Rheology: Fundamental Overview and Applications

Interfacial Rheology: Fundamental Overview and Applications Overview Interfacial rheology dominates the behavior of many complex fluid systems. Whether the system is characterized by a fluid-fluid interface or fluid-air interface, these characteristics influence the behavior of biological systems, oil recovery, personal care products, food and more. Learn the basic forces that drive interfacial dynamics and…

Biophysical Characterization of Antibody Drug Conjugates Using DSC

Biophysical Characterization of Antibody Drug Conjugates Using DSC   In this webinar, Dr. Colette Quinn discusses the use of differential scanning calorimetry (DSC) in protein stability characterization differences resulting from preparation changes of identical systems. Protein stability, particularly antibodies, can be determined via DSC without restrictions on buffers, excipients, and detergents. DSC, a native…

Designing New Materials for Additive Manufacturing: Vat Photopolymerization

Designing New Materials for Additive Manufacturing: Vat Photopolymerization Overview 3D printing, or additive manufacturing (AM), provides opportunities to create previously unattainable geometric objects through layer-by-layer fabrication. Novel macromolecular structures and synthetic methods coupled with unique printing methods lead to 3D part generation with micron-scale resolution and tunable to emerging technologies. By tuning polymer structure, printing…

Long Term Stability Analysis of Monoclonal Antibodies

Long Term Stability Analysis of Monoclonal Antibodies Overview Characterization of biopharmaceuticals during all development phases is critical to the candidate selection process and the ongoing production of the active material. Some recent efforts to achieve patient self-administration has required high API concentrations (100-300 mg/mL). Development concerns for the high concentration formulations are denaturation, aggregation and…

Stability Testing of Energetic Materials by Isothermal Microcalorimetry

Stability Testing of Energetic Materials by Isothermal Microcalorimetry Overview This webinar introduces the use of isothermal microcalorimetry for stability measurement of energetic materials. Energetic materials refer to materials, chemicals and substances which exhibit a risk for self-decomposition associated with self-heating ultimately resulting in run-way reactions. Such materials include propellants, percarbonates and peroxides, and these…

Introducing the New TAM Air Isothermal Calorimeter

Introducing the New TAM Air Isothermal Calorimeter This webinar introduces the all-new TAM Air Isothermal Calorimeter. Delivering the performance, reliability, and ease-of-use that is the hallmark of TA Instruments products, the new TAM Air maintains its leadership position as the instrument of choice for cement and concrete hydration analysis using ASTM C1702 and C1679, as…

Chris Yakacki: Characterization of Active Shape-Memory Polymers

Chris Yakacki: Characterization of Active Shape-Memory Polymers   The field of stimuli-sensitive polymers has grown rapidly over the past decade. Actively-moving polymers have gained attention and have been proposed for use in applications from shape-changing biomedical devices to morphing structures. This webinar covers the basics of characterizing shape-memory polymers using thermo-mechanical equipment, such as the Q800…