Unlock a New Dimension in your Battery Research Through Isothermal Microcalorimetry

  Overview In order to meet growing market demands for power storage, Lithium ion and new battery chemistries demand higher energy density, longer cycle life, calendar life, and better safety to a lower cost. Isothermal microcalorimetry is a highly sensitive, non-destructive and non-specific tool to characterize these critical performance criteria. Learn how this method provides:…

Elucidating Thermodynamic Details of Biologic and Small Molecule Drugs using Microcalorimetry

Overview Researchers are working tirelessly to understand the basic chemical details of viral pathogenesis, viral protein structures, and identifying therapeutics to disrupt and prevent disease. There are different modes of therapies evolving that include small-molecule antiviral drugs, mRNA, and protein-based vaccines. Microcalorimetry is one powerful tool for the development and characterization of the mechanism of…

Biophysical Characterization of Antibodies in a Suspension: Solutions for Slurries

  Overview Differential Scanning Calorimetry (DSC) is typically used during biopharmaceutical development to characterize a biomolecule through its thermal stability and unfolding profile. Here we demonstrate the suitability of DSC for studies of opaque solutions and slurries. Because of its universal indicator, heat, the technique can be applied to samples with magnetic or polystyrene beads,…

Isothermal Microcalorimetry in Pharmaceutical Science

Isothermal Microcalorimetry in Pharmaceutical Science This webinar will review the microcalorimetric techniques that are most commonly used within pharmaceutical science, including stability and compatibility tests, determination of small amounts of amorphic content, and characterizing polymorphism. A microcalorimeter can quantify the amount and rate of heat release from chemical processes associated with stability and shelf…

Biophysical Characterization of Antibody Drug Conjugates Using DSC

Biophysical Characterization of Antibody Drug Conjugates Using DSC   In this webinar, Dr. Colette Quinn discusses the use of differential scanning calorimetry (DSC) in protein stability characterization differences resulting from preparation changes of identical systems. Protein stability, particularly antibodies, can be determined via DSC without restrictions on buffers, excipients, and detergents. DSC, a native…

Long Term Stability Analysis of Monoclonal Antibodies

Long Term Stability Analysis of Monoclonal Antibodies Overview Characterization of biopharmaceuticals during all development phases is critical to the candidate selection process and the ongoing production of the active material. Some recent efforts to achieve patient self-administration has required high API concentrations (100-300 mg/mL). Development concerns for the high concentration formulations are denaturation, aggregation and…

Evolved Gas Analysis: TGA/FTIR

Evolved Gas Analysis: TGA/FTIR Overview Interested in detecting and identifying the presence of residual solvents in your formulation? Would you like to determine the thermal decomposition mechanism of your material? Thermogravimetric analysis (TGA) directly measures weight change of a material as it is heated over a temperature range in a controlled atmosphere. If observing a…

Stability Testing of Energetic Materials by Isothermal Microcalorimetry

Stability Testing of Energetic Materials by Isothermal Microcalorimetry Overview This webinar introduces the use of isothermal microcalorimetry for stability measurement of energetic materials. Energetic materials refer to materials, chemicals and substances which exhibit a risk for self-decomposition associated with self-heating ultimately resulting in run-way reactions. Such materials include propellants, percarbonates and peroxides, and these…

Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability

Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability This webinar is focused on enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics. Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of…