Innovation in materials science is a continuous pursuit, driven by the demand for lighter, stronger, more durable, and more reliable components. This is especially critical in the aerospace and defense industries, where materials must perform reliably under extreme conditions—including intense mechanical stress, wide temperature fluctuations, and long-term environmental exposure.
DetailsDrug development is a long and complex process that starts with discovery and, if successful, ends with government approval for marketing. Each step in the drug development process, outlined below, has specific goals with the aim of down-selecting appropriate hits and candidates to an approved drug substance.
DetailsThe world is driven by battery power, and the various battery testing laboratory applications help to ensure that we get the most out of them.
DetailsAntibody stability is crucial for antibody performance in therapeutics. High antibody thermostabilities are essential for creating products with a reasonable shelf life and avoiding problems with deterioration of the biophysical properties of the antibody.
DetailsLithium-ion batteries are transforming key industries through efficient power storage. Today’s battery scientists must build upon previous discoveries while focusing on the battery elements that will drive progress in leading application areas.
DetailsThroughout the 18th century, many scientists questioned the nature of heat. Isaac Newton thought that heat was transferred by the vibrations of particles, while Robert Hooke believed heat was a property of the body that arose from the motion of its parts.
DetailsThe stability of high-concentration drugs can change under storage conditions, but until now, thermal testing in the lab using traditional calorimetry methods has been time-consuming and challenging. The new TA Instruments RS-DSC fills a critical antibody formulation development gap by allowing for high-throughput short-term thermal stability testing at formulation strength concentrations. In this blog, we explore why that’s essential.
DetailsThe most popular tool used to characterize binding in the late-discovery phase of drug development is isothermal titration calorimetry (ITC). ITC is a high-resolution method for complete characterization of the basic chemical details of a binding interaction. The calorimeters accomplish this by measuring the heat that is released or absorbed when molecules interact with each other.
DetailsGene therapy is an approach to disease treatment where a patient’s genetic makeup is altered rather than using drugs or surgery. Gene therapy treatment is accomplished through the activation of a particular gene, repairing faulty genes, or introducing new genes to help fight disease.
DetailsLyophilization, also called freeze-drying, is the process of removing water from a sample, often for preservation. Lyophilization involves the sublimation of a sample’s water content, usually through a rapid freezing process. Freezing materials quickly helps avoid the destruction of the cell walls in the sample from the formation of large ice crystals.
DetailsThe development of biopharmaceuticals demands precise thermal stability characterization to ensure efficacy, safety, and manufacturability. As the industry shifts toward high concentration biologic formulations and subcutaneous delivery methods, the need for innovative DSC solutions becomes increasingly critical.
DetailsPharmaceutical research and discovery rely on accurate characterization of molecular interactions to develop effective and safe drugs. Isothermal Titration Calorimetry (ITC) is a gold-standard technique that provides critical insights into binding affinity, thermodynamics, and stoichiometry—essential components in Structure-Activity Relationship (SAR) studies.
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