Thermal analysis is a branch of material science that studies how a material’s properties change with temperature. From safe medicines to durable airplanes, countless products are made possible through thermal analysis. Understanding a material’s behavior under different temperatures is crucial for the successful design, processing, end use, and recyclability of completed products.
DetailsThe glass transition temperature (Tg) is a fundamental material property for defining material integrity, manufacturing conditions, and operating guidelines across applications such as polymers, electronics, and advanced materials.
DetailsAntibody-drug conjugates (ADCs) are a cutting-edge class of biopharmaceuticals transforming oncology treatment with increased specificity and efficacy. Their impact is only growing, as 14 ADCs have received global market approval to date and hundreds more are in development.
DetailsWhether it’s the viscosity of hydrogels (for wound care or tissue regeneration) or the yield stress of topicals (like acne or antifungal creams), pharmaceutical manufacturers rely on rheology to monitor and eradicate defects in every batch, ensuring that when the treatment reaches the patient, it remains safe and effective.
DetailsITC is the most sensitive method for characterizing binding interactions, revealing critical attributes like drug efficacy and stability. But without proper mixing, ITC data is unreliable and unusable. Great ITC experiments start with correct mixing.
DetailsDifferential Scanning Calorimetry is a thermal analysis technique commonly used to characterize materials across a broad array of applications including chemistry, biochemistry, pharmaceuticals, polymers, and more. Differential Scanning Calorimetry (DSC) measures the heat flow in a material as it is heated or cooled over a specified temperature range.
DetailsDiscover the RS-DSC from TA Instruments, the ultimate high throughput DSC for rapid thermal analysis. Learn more about its precision, speed, and capabilities.
DetailsBiologic therapies derived from living organisms have revolutionized the treatment of complex diseases, yet their high development costs are often passed onto patients. Biosimilar drugs offer a promising solution to reduce costs while maintaining therapeutic efficacy. Unlike generic drugs, biosimilars cannot be exact replicas of their reference biologics due to their complex structures, necessitating rigorous testing and regulatory approval.
DetailsThe stability of high-concentration drugs can change under storage conditions, but until now, thermal testing in the lab using traditional calorimetry methods has been time-consuming and challenging. The new TA Instruments RS-DSC fills a critical antibody formulation development gap by allowing for high-throughput short-term thermal stability testing at formulation strength concentrations. In this blog, we explore why that’s essential.
DetailsThe method of drug delivery significantly influences the final stages of the manufacturing process. Currently, lyophilization—a widely adopted technique—enables drug developers to stabilize formulations and therapeutic molecules using a validated commercial approach. In this process, precise control of pressure and temperature within a lyophilizer facilitates the removal of liquids from formulations containing thermally sensitive or hydrolytically unstable active pharmaceutical ingredients or formulation components.
DetailsThe progression from formulation development to commercial formulation is dependent on the dose strength, intrinsic stability, and extent of protein self-association in the final drug.1 This is because the drug is reaching the final stage of development.
DetailsCandidate selection is the third phase of the drug development process. The main purpose of candidate selection is to continue screening and filtering down to the most promising antibodies, ideally having one or two progress forward. During this phase, researchers are looking to evaluate the developability of a pool of less than five antibodies.
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