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Unlocking Stability: The Crucial Role of Thermal Analysis in Lyophilization Temperature Optimization

The method of drug delivery significantly influences the final stages of the manufacturing process. Currently, lyophilization—a widely adopted technique—enables drug developers to stabilize formulations and therapeutic molecules using a validated commercial approach. In this process, precise control of pressure and temperature within a lyophilizer facilitates the removal of liquids from formulations containing thermally sensitive or hydrolytically unstable active pharmaceutical ingredients or formulation components.

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Characterization Considerations when Sourcing PCR

Against the backdrop of a plastic waste crisis, the global demand for plastic is set to quadruple by 2060. This has driven a shift toward sustainability and away from linear use models of plastic production. Post-consumer resin (PCR) has emerged as a key player in circular economy initiatives, though ensuring the quality and performance of PCR requires several characterization considerations.

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Applying Dynamic Mechanical Analysis (DMA) to Test the Durability of Protective Sports Equipment

There is a renewed interest in the durability of protective sports equipment after Patrick Mahomes’ helmet recently cracked apart in -4 degrees Fahrenheit (-20 degrees Celsius) weather. Scientists from TA Instruments ran tests to find out if materials found in protective sports equipment can break due to cold weather.

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How to Assess Binding in Drug Discovery

The most popular tool used to characterize binding in the late-discovery phase of drug development is isothermal titration calorimetry (ITC). ITC is a high-resolution method for complete characterization of the basic chemical details of a binding interaction. The calorimeters accomplish this by measuring the heat that is released or absorbed when molecules interact with each other.

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