Freeze drying (lyophilization) is critical to biopharmaceutical stability, and understanding key thermal transitions is essential for developing robust, efficient processes. In this webinar, discover how Differential Scanning Calorimetry (DSC) and Modulated DSC® (MDSC®) help identify critical thermal properties, including the glass transition temperature (Tg′), to optimize cycle design, improve product quality, and reduce development risk. Through practical examples and real-world data, learn how these techniques reveal subtle thermal events and minimize trial-and-error during lyophilization development.

What you’ll learn:

• Differentiate between DSC and MDSC and their analytical capabilities.
• Understand the importance of Tg′ in formulation stability and process design.
• Interpret MDSC data to evaluate formulation and process variables.
• Apply thermal analysis insights to optimize lyophilization cycles and reduce risk.

Samuel Redstone, PhD, is an Applications Scientist supporting the Microcalorimetry and Thermal Analysis product portfolio at Waters Materials Sciences. In his role, he provides application expertise, conducts instrument demonstrations, and delivers technical training to help customers solve complex analytical challenges. Since joining TA Instruments in 2021, Sam has worked closely with researchers across a range of industries to apply thermal analysis techniques for material and formulation characterization. He earned his PhD in Chemistry from the University of Utah, where he conducted research in the laboratory of Professor Cynthia Burrows, studying the relationship between oxidative DNA damage and repair, with a particular focus on the impact of oligonucleotide structure on these processes.